High-level power optimisation for Digital Signal Processing in Recon gurable Logic

This thesis is concerned with the optimisation of Digital Signal Processing (DSP) algorithm implementations on recon gurable hardware via the selection of appropriate word-lengths for the signals in these algorithms, in order to minimise system power consumption. Whilst existing word-length optimisation work has concentrated on the minimisation of the area of algorithm implementations, this work introduces the rst set of power consumption models that can be evaluated quickly enough to be used within the search of the enormous design space of multiple word-length optimisation problems. These models achieve their speed by estimating both the power consumed within the arithmetic components of an algorithm and the power in the routing wires that connect these components, using only a high-level description of the algorithm itself. Trading o a small reduction in power model accuracy for a large increase in speed is one of the major contributions of this thesis. In addition to the work on power consumption modelling, this thesis also develops a new technique for selecting the appropriate word-lengths for an algorithm implementation in order to minimise its cost in terms of power (or some other metric for which models are available). The method developed is able to provide tight lower and upper bounds on the optimal cost that can be obtained for a particular word-length optimisation problem and can, as a result, nd provably near-optimal solutions to word-length optimisation problems without resorting to an NP-hard search of the design space. Finally the costs of systems optimised via the proposed technique are compared to those obtainable by word-length optimisation for minimisation of other metrics (such as logic area) and the results compared, providing greater insight into the nature of wordlength optimisation problems and the extent of the improvements obtainable by them

William John Adie: the man behind the syndrome

William John Adie was an Australian neurologist in the early 20th century responsible for extensively describing the tonically dilated pupil associated with absent deep tendon reflexes – both features of a syndrome that now bears his name. In addition to other neurological syndromes, he was also significant in delineating narcolepsy through his clinical essays and case series. His ophthalmic and neurologic contributions have served the test of time and played an important role in the modern understanding of Adie syndrome and narcolepsy. This report reviews Adie's medical contributions, extensive descriptions of Adie syndrome, and provides a brief biographical account of his life

Social networks : the future for health care delivery

With the rapid growth of online social networking for health, health care systems are experiencing an inescapable increase in complexity. This is not necessarily a drawback; self-organising, adaptive networks could become central to future health care delivery. This paper considers whether social networks composed of patients and their social circles can compete with, or complement, professional networks in assembling health-related information of value for improving health and health care. Using the framework of analysis of a two-sided network – patients and providers – with multiple platforms for interaction, we argue that the structure and dynamics of such a network has implications for future health care. Patients are using social networking to access and contribute health information. Among those living with chronic illness and disability and engaging with social networks, there is considerable expertise in assessing, combining and exploiting information. Social networking is providing a new landscape for patients to assemble health information, relatively free from the constraints of traditional health care. However, health information from social networks currently complements traditional sources rather than substituting for them. Networking among health care provider organisations is enabling greater exploitation of health information for health care planning. The platforms of interaction are also changing. Patient-doctor encounters are now more permeable to influence from social networks and professional networks. Diffuse and temporary platforms of interaction enable discourse between patients and professionals, and include platforms controlled by patients. We argue that social networking has the potential to change patterns of health inequalities and access to health care, alter the stability of health care provision and lead to a reformulation of the role of health professionals. Further research is needed to understand how network structure combined with its dynamics will affect the flow of information and potentially the allocation of health care resources

2D constraint modifies packing behaviour: a halobenzene monolayer with X3 halogen-bonding motif.

Using a combination of X-ray diffraction and simulation techniques, we are able to identify a crystalline monolayer of 1,3,5-triiodotrifluorobenzene formed on graphite. The monolayer is found to exhibit an incommensurate hexagonal unit cell with a lattice parameter of 9.28(7) Å, exhibiting a trigonal arrangement of iodine atoms not found in the bulk structure. DFT simulations have been performed exhibiting close agreement with the experimental structure. Importantly these simulations can be used to compare the strength of the intermolecular interactions both with and without Van der Waals corrections. Thus it is possible to estimate that halogen bonding consists of approximately half the total interaction energy. This demonstrates that despite the presence of strong directional non-covalent bonding, dispersion interactions account for a very significant proportion of the total energy

Coordinated assembly and release of adhesions builds apical junctional belts during de novo polarisation of an epithelial tube

Using the zebrafish neural tube as a model, we uncover the in vivo mechanisms allowing the generation of two opposing apical epithelial surfaces within the centre of an initially unpolarised, solid organ. We show that Mpp5a and Rab11a play a dual role in coordinating the generation of ipsilateral junctional belts whilst simultaneously releasing contralateral adhesions across the centre of the tissue. We show that Mpp5a and Rab11a-mediated resolution of cell-cell adhesions are both necessary for midline lumen opening and contribute to later maintenance of epithelial organisation.We propose that these roles for both Mpp5a and Rab11a operate through the transmembrane protein Crumbs. In light of a recent conflicting publication, we also clarify that the junction-remodelling role of Mpp5a is not specific to dividing cells

Lifestyle Medicine Professionals in Training: A Survey of Behaviors, Knowledge and Needs

Background/Purpose: It is well known that healthy lifestyle habits can influence chronic disease risk and outcomes. The effective practice of Lifestyle Medicine (LM), however, goes beyond general recommendations and has been encapsulated in well-defined clinical competencies. While it has been documented that graduating medical students feel inadequately prepared to counsel patients in nutrition and exercise, the purpose of this study is to explore the perceptions and experiences of Lifestyle Medicine in a group of interdisciplinary healthcare trainees. Methods: A pilot survey of trainees at the 2015 Annual American College of Lifestyle Medicine (ACLM) Conference assessed perspectives on the inclusion of nutrition and exercise in their educational curricula, knowledge of core LM competencies and personal health habits. Results: Of the 37 trainees registered, 22 surveys were completed. Twenty-six percent indicated they were exposed to courses in exercise; sixty-five percent reported having a nutrition block and fifty percent received instruction on counseling about LM behaviors. Relative importance using Likert scale (1-not important, 5-very important) ascribed similar levels of importance to exercise (4.44), nutrition (4.31), and behavioral counseling (4.58) training. Ninety-five percent reported personal engagement in physical activity, however only forty-two percent were familiar with the Lifestyle Medicine core competencies. Ninety-four percent indicated that the current medical model was insufficient in educating trainees to address lifestyle related diseases. Conclusion: In a select multidisciplinary sample of trainees, there is recognition of the importance of Lifestyle Medicine training. Although trainees surveyed practice healthful behaviors, the majority were not familiar with core Lifestyle Medicine competences and express strong interest in increased Lifestyle Medicine in their training experience

The twin faces of public sector design

Design thinking has become a popular approach for governments around the world seeking to address complex governance challenges. It offers novel techniques and speaks to broader questions of who governs, how they govern, and the limits of rational instrumentalism in policy making. Juxtaposing design thinking with an older tradition of policy design, this article offers the first critical analysis of the application of design thinking to policy making. It argues that design thinking does not sufficiently account for the political and organizational contexts of policy work. Design thinking also errs in universally privileging one particular policy style over others, and fails to account for the reality of policy mixes. Despite these deficiencies, it is argued that design thinking can inform and enrich governance by helping policy designers produce more adaptable designs, better appreciate the behavioral dynamics of public sector design, and leverage networked approaches to social problem solving

Effects of lipid kinase expression and cellular stimuli on phosphatidylinositol 5-phosphate levels in mammalian cell lines

AbstractPhosphatidylinositol 5-phosphate (PtdIns5P) is a relatively recently discovered inositol lipid whose metabolism and functions are not yet clearly understood. We have transfected cells with a number of enzymes that are potentially implicated in the synthesis or metabolism of PtdIns5P, or subjected cells to a variety of stimuli, and then measured cellular PtdIns5P levels by a specific mass assay. Stable or transient overexpression of Type IIα PtdInsP kinase, or transient overexpression of Type Iα or IIβ PtdInsP kinases caused no significant change in cellular PtdIns5P levels. Similarly, subjecting cells to oxidative stress or EGF stimulation had no significant effect on PtdIns5P, but stimulation of HeLa cells with a phosphoinositide-specific PLC-coupled agonist, histamine, caused a 40% decrease within 1min. Our data question the degree to which inositide kinases regulate PtdIns5P levels in cells, and we discuss the possibility that a significant part of both the synthesis and removal of this lipid may be regulated by phosphatases and possibly phospholipases

The Influence of Particle Concentration on the Formation of Settling-Driven Gravitational Instabilities at the Base of Volcanic Clouds

Settling-driven gravitational instabilities observed at the base of volcanic ash clouds have the potential to play a substantial role in volcanic ash sedimentation. They originate from a narrow, gravitationally unstable region called a Particle Boundary Layer (PBL) that forms at the lower cloud-atmosphere interface and generates downward-moving ash fingers that enhance the ash sedimentation rate. We use scaled laboratory experiments in combination with particle imaging and Planar Laser Induced Fluorescence (PLIF) techniques to investigate the effect of particle concentration on PBL and finger formation. Results show that, as particles settle across an initial density interface and are incorporated within the dense underlying fluid, the PBL grows below the interface as a narrow region of small excess density. This detaches upon reaching a critical thickness, that scales with (ν2/g′)1/3, where ν is the kinematic viscosity and g′ is the reduced gravity of the PBL, leading to the formation of fingers. During this process, the fluid above and below the interface remains poorly mixed, with only small quantities of the upper fluid phase being injected through fingers. In addition, our measurements confirm previous findings over a wider set of initial conditions that show that both the number of fingers and their velocity increase with particle concentration. We also quantify how the vertical particle mass flux below the particle suspension evolves with time and with the particle concentration. Finally, we identify a dimensionless number that depends on the measurable cloud mass-loading and thickness, which can be used to assess the potential for settling-driven gravitational instabilities to form. Our results suggest that fingers from volcanic clouds characterised by high ash concentrations not only are more likely to develop, but they are also expected to form more quickly and propagate at higher velocities than fingers associated with ash-poor clouds.</jats:p